The mTORC1 Inhibitor Everolimus Prevents and Treats Em- Myc Lymphoma by Restoring Oncogene-Induced Senescence
نویسندگان
چکیده
Meaghan Wall 1 , 3 , 4 , Gretchen Poortinga 1 , 3 , Kym L. Stanley 1 , Ralph K. Lindemann 1 , 13 , Michael Bots 1 , Christopher J. Chan 1 , 9 , Megan J. Bywater 1 , Kathryn M. Kinross 1 , Megan V. Astle 1 , Kelly Waldeck 1 , Katherine M. Hannan 1 , Jake Shortt 1 , 3 , Mark J. Smyth 1 , 6 , 7 , Scott W. Lowe 11 , 12 , Ross D. Hannan 1 , 5 , 7 , 8 , 10 , Richard B. Pearson 1 , 5 , 7 , 8 , Ricky W. Johnstone 1 , 6 , 7 , and Grant A. McArthur 1 , 2 , 3 , 6 , 7 RESEARCH ARTICLE
منابع مشابه
The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.
UNLABELLED MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in Eμ-Myc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell lymphoproliferative disorders. Deregulated expression of MYC results in increased mTOR complex 1 (mTORC1) signaling. As tumors with mTORC1 activation are sensitive to mTORC1 inhibition, we used everolimus, a potent ...
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